D4.2 Intelligent D-Band wireless systems and networks initial designs

This deliverable gives the results of the ARIADNE project's Task 4.2: Machine Learning based network intelligence. It presents the work conducted on various aspects of network management to deliver system level, qualitative solutions that leverage diverse machine learning techniques. The different chapters present system level, simulation and algorithmic models based on multi-agent reinforcement learning, deep reinforcement learning, learning automata for complex event forecasting, system level model for proactive handovers and resource allocation, model-driven deep learning-based channel estimation and feedbacks as well as strategies for deployment of machine learning based solutions. In short, the D4.2 provides results on promising AI and ML based methods along with their limitations and potentials that have been investigated in the ARIADNE project

MiR-185-5p regulates the development of myocardial fibrosis

Background: Cardiac fibrosis stiffens the ventricular wall, predisposes to cardiac arrhythmias and contributes to the development of heart failure. In the present study, our aim was to identify novel miRNAs that regulate the development of cardiac fibrosis and could serve as potential therapeutic targets for myocardial fibrosis. Methods and results: Analysis for cardiac samples from sudden cardiac death victims with extensive myocardial fibrosis as the primary cause of death identified dysregulation of miR-185-5p. Analysis of resident cardiac cells from mice subjected to experimental cardiac fibrosis model showed induction of miR-185-5p expression specifically in cardiac fibroblasts. In vitro, augmenting miR-185-5p induced collagen production and profibrotic activation in cardiac fibroblasts, whereas inhibition of miR-185-5p attenuated collagen production. In vivo, targeting miR-185-5p in mice abolished pressure overload induced cardiac interstitial fibrosis. Mechanistically, miR-185-5p targets apelin receptor and inhibits the anti-fibrotic effects of apelin. Finally, analysis of left ventricular tissue from patients with severe cardiomyopathy showed an increase in miR-185-5p expression together with pro-fibrotic TGF-beta 1 and collagen I. Conclusions: Our data show that miR-185-5p targets apelin receptor and promotes myocardial fibrosis.Peer reviewe

Unity-pelialustan moninpeliominaisuudet

Opinnäytetyön tavoitteena oli tutkia ja kokeilla Unity-pelinkehitysalustan moninpeliominaisuuksia. Työ jaettiin kahteen erilliseen osaan. Näistä ensimmäisessä kehitettiin Unityä käyttäen pelisovellus, joka mahdollistaa usean päätelaitteen välisen moninpelaamisen ilman erillistä palvelinta. Toisessa vaiheessa tehtiin selvitystyö Unitylle työn tekohetkellä saatavilla olevista moninpelattavien virtuaalimaailmojen luomiseen soveltuvista palvelinratkaisuista. Ensimmäisen vaiheen toteutuksessa käytettiin pääasiallisena työkaluna toimineen Unityn lisäksi Microsoftin Visual Studio 2012:ta sekä Googlen Android-kehitystyökaluja. Ohjelmakoodia kirjoitettiin C#- ja Java-ohjelmointikielillä. Toisessa vaiheessa selvitystyötä tehtiin internetiä ja selvitystyön kohteeksi valittujen tuotteiden dokumentaatiota lähteinä käyttäen. Tuotteisiin suoraan liittyvän materiaalin lisäksi tutkittiin esimerkiksi tuotteita koskevaa verkkokeskustelua ja tuotteita käyttäviä sovelluksia. Työn tuloksena syntyi peliohjelma, joka mahdollistaa yksinkertaisen pallopelin pelaamisen Android- ja PC-laitteilla. Selvitystyön pääasialliset tulokset on kirjattu tämän opinnäytetyön liitteistä löytyvään taulukkoon sekä raportin viidenteen lukuun, joka käsittelee selvitystyötä ja tutkittuja tuotteita.The main subject of this thesis work is Unity game development platform and its multiplayer features. The work itself was divided into two independent stages. In the first stage the goal was to develop a multiplayer gaming application. The most important requirement was that using the application to play multiplayer games should not require a dedicated server. The aim of the second stage was to research Unity compatible multiplayer server solutions currently available on the market. Focus was on such solutions that enable the creation of persistent virtual worlds. Main tools used in the first stage were Unity, Visual Studio 2012 and Android SDK. Programming was done in C# and Java. Information for the second stage was acquired using the internet and the documentation of the solutions selected for comparison

Critical study of the applicability of additional IAQ sensors in older buildings

This research assesses whether the perceived indoor air quality (IAQ) can be improved with additional sensors in older buildings. The research does not investigate IAQ in its broadest sense, but focus on phenomena perceived by the human senses, such as thermal comfort. The effects of the maintenance of technical systems on perceived IAQ are also studied. In the study, 2506 sensors were installed in 29 public buildings in nine cities in Finland. The change in studied indicators was measured over four years and compared to 65 buildings in the comparison group. The study provides an objective view of the usefulness of BAS-connected and cloud-based sensors. The study also shows that a building owner considering introducing cloud technology to improve perceived IAQ should also be prepared to reform property maintenance processes. The study showed that additional sensors connected to the BAS improve thermal stability. No such improvement was observed in sensors connected to cloud services.</p

MiR‐185‐5p regulates the development of myocardial fibrosis

Abstract Background: Cardiac fibrosis stiffens the ventricular wall, predisposes to cardiac arrhythmias and contributes to the development of heart failure. In the present study, our aim was to identify novel miRNAs that regulate the development of cardiac fibrosis and could serve as potential therapeutic targets for myocardial fibrosis. Methods and results: Analysis for cardiac samples from sudden cardiac death victims with extensive myocardial fibrosis as the primary cause of death identified dysregulation of miR‐185‐5p. Analysis of resident cardiac cells from mice subjected to experimental cardiac fibrosis model showed induction of miR‐185‐5p expression specifically in cardiac fibroblasts. In vitro, augmenting miR‐185‐5p induced collagen production and profibrotic activation in cardiac fibroblasts, whereas inhibition of miR‐185‐5p attenuated collagen production. In vivo, targeting miR‐185‐5p in mice abolished pressure overload induced cardiac interstitial fibrosis. Mechanistically, miR‐185‐5p targets apelin receptor and inhibits the anti-fibrotic effects of apelin. Finally, analysis of left ventricular tissue from patients with severe cardiomyopathy showed an increase in miR‐185‐5p expression together with pro-fibrotic TGF‐β1 and collagen I. Conclusions: Our data show that miR‐185‐5p targets apelin receptor and promotes myocardial fibrosis